Harvard Study Links Lack of Sleep to Increased Diabetes and Obesity Risk

Harvard Medical School and Brigham and Women’s Hospital (BWH) researchers have found that sleep restriction and circadian disruption impairs glucose regulation and metabolism.

Too little sleep or sleep patterns that are inconsistent with our body’s “internal biological clock”, such as when performing shift work, may lead to increased risk of diabetes and obesity. Previous research has found the same thing in short-term lab studies and epidemiological studies.

However, unlike epidemiological studies, this new Harvard/BWH study provides support by examining humans in a controlled lab environment over a prolonged period, and altering the timing of sleep, mimicking shift work or recurrent jet lag. The study was published in the journal Science Translational Medicine.

Researchers hosted 21 healthy participants in a completely controlled environment for nearly six weeks. The researchers controlled how many hours of sleep participants got, as well as when they slept, and other factors such as activities and diet. Participants started with getting optimal sleep (approximately 10 hours per night). This was followed by three weeks of 5.6 hours of sleep per 24-hour period and with sleep occurring at all times of day and night, thereby simulating the schedule of rotating shift workers.

Thus, during this period, there were many days when participants were trying to sleep at unusual times within their internal circadian cycle-the body’s “internal biological clock” that regulates sleep-wake and many other processes within our bodies. The study closed with the participants having nine nights of recovery sleep at the usual time.

The Harvard/BWH researchers saw that prolonged sleep restriction with simultaneous circadian disruption decreased the participants’ resting metabolic rate. Moreover, during this period, glucose concentrations in the blood increased after meals, because of poor insulin secretion by the pancreas.

A decreased resting metabolic rate could translate into a yearly weight gain of over 10 pounds if diet and activity are unchanged. Increased glucose concentration and poor insulin secretion could lead to an increased risk for diabetes.

“We think these results support the findings from studies showing that, in people with a pre-diabetic condition, shift workers who stay awake at night are much more likely to progress to full-on diabetes than day workers,” said Orfeu M. Buxton, PhD, of Harvard and BWH. “Since night workers often have a hard time sleeping during the day, they can face both circadian disruption working at night and insufficient sleep during the day.”

Reference:

Science Translational Medicine.11 April 2012: Vol. 4, Issue 129, p. 129ra43 “Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption” Orfeu M. Buxton1,2, Sean W. Cain1,2, Shawn P. O’Connor1, James H. Porter1, Jeanne F. Duffy1,2, Wei Wang1,2, Charles A. Czeisler1,2 and Steven A. Shea1,2 Author Affiliations: 1 Division of Sleep Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, 2 Division of Sleep Medicine, Harvard Medical School, Boston, MA.

This research was supported by the National Institute on Aging; National Heart, Lung and Blood Institute; National Center for Research Resources; Center for Clinical Investigation of the Harvard Clinical and Translational Science Center; Joslin Diabetes and Endocrinology Research Center Service Specialized Assay Core; the National Space Biomedical Research Institute; and Natural Sciences and Engineering Research Council of Canada.